UniLectin exploration platform and database for curated and predicted lectin carbohydrate binding proteins
Introduction

Every year more proteins are publicly available thanks to the new genomes sequenced and the effort made in the prediction of encoded proteins, either by HMM tools or by using and transcriptome as reference. Specialized databases are released for species or specific types of RNA, proteins and pathways. Glycoscience study complex carbohydrates and especially their relationships with protein and lipids. In the domain of Glycoscience there is only a few information available and to help future research it is necessary to develop online databases. Lectins are carbohydrate-binding proteins, macromolecules that are highly specific for sugar moieties. Lectins perform recognition on the cellular and molecular level and play numerous roles in biological recognition mechanisms involving cells, carbohydrates, and proteins. Lectins also mediate attachment and binding of bacteria and viruses to their intended targets. UniLectin provides information on the protein and the structure for a large number of lectin families.

To stay always maintained and updated, Lectin3D 2.0 provides new management utilities to facilitate the addition of new lectins. Those utilities are available in advanced mode. If you're interested in the database managaement and development please contact us

Lectin3D V2

The new version of lectin3D provides a more direct lectin research interface. The lectins categories are displayed in both a sunburst and a tree to facilitate the exploration. The research interface provides multiples criteria to select specific lectins or structures. For every structure multiple manually curated informations are available, mostly about the associate carbohydrate.

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On the lectin category sunburst, the multiples PDB structures available in each order class and families can be explored. The taxonomic tree also allws to explore the classification with the tree leafs which can be clicked to expand the tree and access subcategories. The final leaf open the detailed structure informations.

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The research interface allows to select subset of lectins, or lectins structures based on multiples criteria.

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Explore lectins by protein ID

The lectins can be explored by protein uniprot ID and the multiple PDB structures available are displayed in the results.

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Explore lectins by PDB structure

The lectins can be explored by struture. Each structure is related to a protein with an ID uniprot. For each structure the other structure from the same protein are proposed in the results.

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The Lectin entries is classified by order class families categories in function of the carbohydrate binding site and the species.

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Litemol allows to visualize in details the protein 3D structure, zoom on specific residues to see the carbohydrate - protein interactions

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The PDBe functionaol domain viewer provides information on the glycosilated sites, functional domain, carbohydrates binding sites